Dr. Varun Goel

Professional Journey

AWARD

• Health Icon of the Year – Golden Star Awards 2016 by National Institute for Education Research (NIER).
• Medical excellence award 2020 by national institute for education research (NIER).

DIPLOMATE NATIONAL BOARD THESIS GUIDE

Presently Thesis co-guide for DNB medical oncology students in the department of Medical Oncology Rajiv Gandhi Cancer Institute & Research Center for diplomate national board for Medical Oncology.

• Dr Udeep (2016): Role of capecitabine Maintenance chemotherapy in inoperable and Metastatic Carcinoma Stomach patients.
• Dr. Amrith Patel (2017) : Frontline Folfox chemotherapy in metastatic carcinoma stomach patients.

PUBLICATIONS AND RESEARCH WORK

(* as first author)

• * Hepatic osteodystrophy. Trop Gastroenterol. 2010;31:82-6.
• *Chemokine receptor 5 (CCR5) polymorphism in chronic hepatitis B patients treated with three different nucleos(t)ide analogues. Indian J Med Res. 2013;137:1208-9.
• * Trichomegaly of Eyelashes after Treatment with Erlotinib in Carcinoma Pancreas. International Journal of Trichology 2014;6:23-24.
• * Small cell carcinoma of the ovary of hypercalcemic type: a rare tumor. Natl J Med Res. 2014;4:113-115.
• * Primary renal primitive neuroectodermal tumor: A rare presentation. J Postgrad Med. 2015;61:126-8.
• *Case report: Non-small-cell lung carcinoma presenting as a foot swelling. Lung India : Official Organ of Indian Chest Society.
• Two cases of ovarian carcinoma with endobronchial metastases: Rare presentation. South Asian J Cancer 2015;4:149
• *FOLFOX-4 as second-line therapy after failure of gemcitabine and platinum combination in advanced gall bladder cancer patients. Japanese Journal of Clinical Oncology, 2015, 1–6.
• Altretamine in advanced pretreated epithelial ovarian carcinoma patients; experience from a centre in north india. Current Medicine Research and Practice , Volume 6 , Issue 3 , 109 – 112.
• Impact of dengue fever on cancer patients: case series. Current Medicine Research and Practice , Volume 6 , Issue 4 , 157 – 159.
• Gemcitabine and cisplatin in inoperable, loco-regionally advanced and metastatic gallbladder cancer: A study from Northern India cancer institute. Int J Hepatobiliary Pancreat Dis 2016;6:108–113.
• *Efficacy and toxicity of cetuximab with chemotherapy in recurrent and metastatic head and neck cancer: A prospective observational study. Indian J Cancer 2016;53:487-92
• *Study of efficacy and safety of modified adjuvant intraperitoneal chemotherapy regimen in carcinoma ovary. Indian J Cancer. 2016 Oct-Dec;53(4):607-611.
• Gemcitabine and Carboplatin in Inoperable, LocoRegionally Advanced and Metastatic Gallbladder Cancer- A Study from Northern Indian Cancer Institute. British Journal of Medicine & Medical Research, 19(12): 1-7, 2017.
• Unusaual tree bark like skin pigmentation over veins after 5-fluorouracil infusion with spontaneous resolution. International journal of science and research methodology, human. 2017 sep;7(3):26-29.
• A Rare Cause of Headache in Common Cancer: Ovarian Carcinoma with Brain Metastasis. Indian J Gynecol Oncolog (2019) 17: 11.
• Methotrexate induced neurotoxicity: A stroke mimic. International Journal of Medical and Health Research, Volume 4; Issue 4; April 2018; Page No. 32-34.
• Gemcitabine with carboplatin for advanced intrahepatic cholangiocarcinoma: A study from North India Cancer Centre. Indian J Cancer 2018;55:222-5.
• Nab-paclitaxel: An effective third-line chemotherapy in patients with advanced, unresectable gallbladder cancer. Indian J Med Res 2020;152:475-81.
• Maheshwari U, Rajappa SK, Talwar V, Goel V, Dash PK, Sharma M, et al. Adjuvant chemotherapy in uterine carcinosarcoma: Comparison of a doublet and a triplet chemotherapeutic regimen. Indian J Cancer [Epub ahead of print]
• Role of maintenance gemcitabine in metastatic/unresectable gall bladder cancer: prospective study from cancer center in northern India; Accepted and to be published in South Asian Journal of Oncology.
• *A rare gastric malignancy at gastro jejunostomy stump Cancer Research,Statistics and Treatment Apr–Jun 2020 – Volume 3 – Issue 2 – p 312-316
• Manuscript # IJMS_20_2020 titled ” Ecchymoses As a Presenting Sign OF a Solid Malignancy, Accepted for Publication in Indian Journal Of Medical Sciences.
• Dogra A, Talwar V, Goel V, Sekhon R, Rawal SK. First-line chemotherapy analysis on survival in carcinoma ovary patients: Data from a Northern Indian cancer center. J Can Res Ther [Epub ahead of print] [cited 2022 Dec 13]. Available from: https://www.cancerjournal.net/preprintarticle.asp?id=323175
• Efficacy of PARP Inhibitors in the Treatment of Ovarian Cancer: A Literature-Based Review. Asian J Oncol 2019;5:1–18
• Real World Outcomes of Check Point Inhibitors Immunotherapy in Renal and Urothelial Cancers in a Teratiary Care Cancer Center in India. Int J Mol Immuno Oncol 2019;4(3):63-6
• Pancreatic giant cell tumor: a variant of pancreatic adenocarcinoma with aggressive course. Asian J Oncol 2018;4:79-80
• Miliary Brain Metastasis—A Rare Pattern of Metastases from Breast Cancer. South Asian J Cancer 2021.
• Isolated splenic recurrence of treated jejunal cancer: A case report with brief review of literature. ijmpo
• Cancer-related fatigue in carcinoma urinary bladder patients receiving chemotherapy: A single institutional study from northern India. Journal of Clinical Oncology 2019 37:7_suppl, 361-361
• Soft Palate Metastasis A Rare Site Of Metastasis In TCC Of Urinary Bladder. Journal of Medical Sciences 2017; 20(1):47-48.
• Basnet B, Goyal P, Mahawar V, Bothra SJ, Agrawal C, Thapa BB, Talwar V, Jain P, Babu Koyyala VP, Goel V, Batra U, Doval DC. Role of 18F-Flurodeoxyglucose Positron-Emission Tomography/Computed Tomography in the Evaluation of Early Response to Neoadjuvant Chemotherapy in Patients with Locally Advanced Triple-Negative Breast Cancer. Indian J Nucl Med. 2020 Apr-Jun;35(2):105-109.
• Goyal P, Doval DC, Agarwal C, Jain P, Chaudhari K, Domadia K, Redhu P, Koyyala VPB, Goel V, et al. Current Treatment Approaches for Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer in Adjuvant and Neoadjuvant Settings. Ind J Med Paediatr Oncol 2021;42:35–45
• Koyyala VP, Sharma M, Goyal P, Goel V, Bommera S, Agrawal M, Domadia K, Choudhary K, Bothra S, Jajodia A, Amrith B P, Joga S, Pasricha S, Batra U. Epidemiological, clinical profile, and treatment outcome of stage iv nonsquamous nonsmall cell lung cancer patients presenting to tertiary care hospital in North India. Oncol J India 2021;5:104-10.
• Study of efficacy and toxicity profile of gemcitabine and erlotinib based chemotherapy regimen in locally advanced (inoperable) and metastatic carcinoma pancreas. European Journal of Molecular &Clinical Medicine. Volume08,Issue04,2021.
• Domadia K, Goel V, Koyyala VPB, Patnaik N, Chaudhari K, Raina S, et al. Study of Gemcitabine Plus Nab-Paclitaxel-Based Chemotherapy Regimen as First-Line Treatmentin Metastatic Pancreatic Carcinoma. South Asian J Cancer 2022;11(1):31–35.
• Agarwal, H., Talwar, V., Anand, S., Goel, V., & Patnaik, N. (2022). Psychological challenges encountered by health care professionals having a risk of accidental exposure and its impact on their wellbeing in a non-covid hospital during the prevailing pandemic.International Journal of Health Sciences,6(S3), 816–822.
• Joga S, Bansal A, Talwar V, Bothra S, Dash P, Goel V, et al. Spontaneous pulmonary arterial embolization : A rare complication of the silicon- based peripherally inserted central venous catheter(PICC). The Journal of Vascular Access. 2022;23(3): 471–3.
• Narayan S, Talwar V, Goel V, Chaudhary K, Sharma A, Redhu P, Soni S, Jain A. Co-relation of SARS-CoV-2 related 30-d mortality with HRCT score and RT-PCR Ct value-based viral load in patients with solid malignancy. World J Clin Oncol. 2022 May 24;13(5):339-351.
• Jajodia, A., Goel, V., Goyal, J., Patnaik, N., Khoda, J., Pasricha, S., Gairola, M. Combined Diagnostic Accuracy of Diffusion and Perfusion MR Imaging to Differentiate Radiation-Induced Necrosis from Recurrence in Glioblastoma. Diagnostics 2022, 12, 718
• Jajodia A, Goel V, Patnaik N, Pasricha S, Gupta G, Batra U, Talwar V. Analysis of Spatial Heterogeneity of Responses in Metastatic Sites in Renal Cell Carcinoma Patients Treated with Nivolumab. Tomography. 2022; 8(3):1363-1373.
• Raffaella Casolino, Chiara Braconi et al. the BABEL working group of the COST Action 18122 (EURO-CHOLANGIO-NET), part of the European Network for the Study of CholangiocarcinomaBridging the equity gap in patient education: the biliary tract cancer BABEL project. Lancet; Volume 23, ISSUE 5, P568-570, May 01, 2022.
• Maheshwari U, Sharma M, Goel V, Goyal P, Jain P, Agarwal C, et al. Clinical Profile and Outcomes of Treatment in Gastric Cancer in Young Patients in India. Asian J Oncol 2022;8:111–118.
• Patnaik N, Pasricha S, Gupta G, Durga G, Sharma SK, Sharma A, Kamboj M, Goel V, Jajodia A, Mehta A. EBV positive diffuse large B-cell lymphoma, NOS in a patient of Crohn’s disease treated with immunomodulator. Indian J Pathol Microbiol 2022;65:739-41
• Goyal P, Jain P, Agrawal C, Bothra S, Talwar V, Batra U, Goyal S, Maheshwari U, Chaudhari K, Goel V, BP A, Doval DC et al. Breast Cancer in Transgenders: Narrative Review. Ind J Med Paediatr Onco. Article published online: 2022-07-28.
• Narayan S, Talwar V, Redhu P, Goel V, Jain A, Soni S, et al. Serpentine Supra-venous Hyperpigmentation “Badge of Courage” in Fight Against Cancer: An Brief Review. Gulf J Oncolog. 2022 Sep;1(40) 83-7.

PUBLICATION / ABSTRACTS

• * Efficacy and safety of adjuvant intraperitoneal chemotherapy in carcinoma ovary: A prospective observational study. J Clin Oncol 34, 2016 (suppl; abstr e17069)
• Efficacy and toxicity of FOLFOX-4 as second-line chemotherapy in locally advanced unresectable and metastatic carcinoma gall bladder: A prospective observational study. J Clin Oncol 32, 2014 (suppl; abstr e15101).
• Neo-adjuvant chemotherapy followed by radical surgery as management of stage IB2 – IIIA cervical cancer in Indian population. Indian J Cancer. 2013 Nov;50 Suppl:S110. (abstract id: 1596)
• Neo-adjuvant chemotherapy followed by surgery vs definitive chemo radiation as treatment for localized carcinoma cervix. Abstract in ECC 2015.
• * Study of efficacy and toxicity profile of gemcitabine and erlotinib based chemotherapy regimen in locally advanced (inoperable) and metastatic (LA/M) carcinoma pancreas. Pancreatology , Volume 16 , Issue 1 , S9
• *NAB-PACLITAXEL as third-line therapy after failure of gemcitabine and 5-FU based combinations in advanced gall bladder cancer patients. Ann Oncol (2016) 27 (suppl_6): 700P.
• Triple negative breast cancer patients with P53 over expression; A clinical correlation study from center in Northern India Indian Journal of Cancer; 50(supplement 1); A-541; 2013.
• * Plasma circulating ctDNA: Potential biomarker in non-small cell lung carcinoma and clinical significance. Journal of Thoracic Oncology (2018) 13 (supp_4): S1-S139.
• * Randomised prospective study of maintenance tamoxifen versus post adjuvant chemotherapy surveillance only in advanced ovarian cancer patients. Annals of Oncology (2017) 28 (suppl_5): v330-v354.
• Incidence of cancer related fatigue (CRF) in Indian women with breast cancer; an overview of psychological issues in breast cancer patients receiving chemotherapy. Tumori Journal abstract book. 2019
• Adoption of molecular testing in breast cancer in a tertiary care center in a developing country. Annals of Oncology. Volume 30, Supplement 9, November 2019, Page ix127
• Rectal cancer in young patients: Clinicoepidemiologic profile and treatment outcomes. Journal of Clinical Oncology 2020 38:15_suppl, 4042-4042
• Analysis of spatial heterogeneity of responses in metastaticsites with nivolumab in renal cell carcinoma. Annals of Oncology. Volume 31-Issue S6-2020. S1324.
• *Study of paclitaxel and ramucirumab as second line therapy after failure of FOLFOX-6 regimen, in metastatic carcinoma stomach patients. Annals of Oncology. 2021
• *Study of efficacy and safety of combination of octreotide acetate LAR with Lenvatinib as second line therapy in patients with advanced G1-G2 NETs of non-pancreatic origin. Annals of Oncology. 2021
• Need for awareness about immune-related adverse events(iRAEs) among community physicians in India. Annals of Oncology. Volume 32-Issue S7-2021. S1405.
• Challenges to molecular testing for selecting targeted therapies for oncology patients in India. Annals of Oncology. Volume 32-Issue S6-2021. S1366.

ONGOING RESEARCH STUDIES IN THE INSTITUTE:

• To estimate the prevalence of BRCA1 and BRCA2 gene mutation positivity in patients of high grade serous epithelial carcinoma of Ovary of North India attending tertiary care hospital in Delhi
• To assess adjuvant chemotherapy related toxicity profile and survival in ovarian cancer patients from center in northern India
• A pilot study to assess BRCA-1 positivity among patients of Pancreatic duct adeno-carcinoma attending tertiary care centre in North India
• A Prospective, Multicentre, Phase-IV Clinical Trial of Olaparib in Indian Patients with Platinum Sensitive Relapsed Ovarian Cancer who are in Complete or Partial Response Following Platinum Based Chemotherapy and Metastatic Breast Cancer with Germline BRCA1/2 Mutation (SOLI Study).
• A Phase III Randomized, Double-Blind, Placebo-Controlled, Multi-Regional, International Study of Durvalumab in Combination with Gemcitabine plus Cisplatin versus Placebo in Combination with Gemcitabine plus Cisplatin for Patients with First-Line Advanced Biliary Tract Cancers (TOPAZ-1).

POSTER PRESENTATIONS :

• Efficacy & safety profile of gemcitabine & erlotinib combination in advanced Ca Pancreas in India. UAE CANCER CONGRESS 2016.
• NAB-PACLITAXEL -as third-line therapy after failure of gemcitabine and 5-FU based combinations in advanced gall bladder cancer patients. ESMO ASIA 2016
• Efficacy and toxicity of cetuximab with chemotherapy in recurrent and metastatic head and neck cancer: A prospective observational study. ASHNO 2017
• Soft palate metastasis – a rare site of metastasis in TCC of urinary bladder. 30th ICON Ahmadabad.
• Transdermal buprenorphine for cancer pain management: experience from a tertiary care centre in northern india. 2018 the Japanese Society of Medical Oncology Annual Meeting.
• Plasma circulating ctDNA: Potential biomarker in non-small cell lung carcinoma and clinical significance. European Lung Cancer Congress (ELCC) 2018.
• Randomised prospective study of maintenance tamoxifen versus post adjuvant chemotherapy surveillance only in advanced ovarian cancer patients. ESMO (European Society for Medical Oncology) 2017.

ORAL PRESENTATIONS:

• Febrile neutropenia : management – Elite Criticlave 2018″ at Prague, Czech Republic.
• Role of immunological drugs as second line therapy in H&N cancer patients – ASHNO 2019, Seoul, Korea.

BOOK CHAPTER:

• CML- Recent Advances in management
• The API Medicine update Vol: XIV 2014.
• Management of Metastatic Breast Cancer
• The API medicine update Vol 25; 2015 ; pg 750-754.
• Endometrial cancer in textbook of oncology. 2019
• Hepato – Biliary Cancers. API Textbook 11th Edition; 2019.
• Hepato – Biliary Cancers. API Textbook 12th Edition; 2021.
• Ovarian cancer. Textbook on clinical oncology. 2020.

ORGANIZING SEMINARS/ WORKSHOPS/CONFERENCE :

• Co-organizing secretary PANCREATIC CANCER conference 2018, theme New Horizons.
• Co-organizing secretary IMMUNO ONCOLOGY SUMMIT 9th Nov 2019 At Delhi

CERTIFICATION GCP TRAINING

• Minimum Criteria for ICH E6 GCP Investigator Site Personnel Training, 2.0, Completed on 20.02.2020