Academic Program

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Pediatric Hematology and Oncology Services

Academic Program

Department of Pediatric Hematology and Oncology

Faculty
Services
Academic Program: National board accredited fellowship in Pediatric Hematology & Oncology (2 years)
Publications
Conferences and Workshops
Current Clinical Trials

Academic Program

The Department of Pediatric Hematology and Oncology is running a two year fellowship program that is accredited by the National Board of Examinations. Two positions are available each year. Trainees on this program are also eligible for taking the exam conducted by the Indian academy of Pediatrics (FIAP). The Fellowship program is structured to provide training for bright, highly motivated candidates seeking careers in Pediatric Hematology Oncology. The clinical service is diverse, drawing patients from all over the country. The high volume and diversity of new diagnoses seen at the institute ensure a uniquely robust training experience in pediatric hematology, oncology and hematopoietic stem cell transplantation. The scientific environment at the institute is excellent with regular multispeciality clinics and a carefully organized didactic curriculum. All this lays emphasis on both fundamental concepts and current advances in the subspeciality.

The trainee is expected to develop a thorough understanding of the pathophysiology of disorders related to Pediatric Hematology / Oncology / SCT and develop skills in the diagnosis, treatment, and management of these disorders. During their training, they additionally should become competent in developing skills related to the selection and evaluation of diagnostic procedures to carry out thorough evaluations of Pediatric Hematology/Oncology/SCT disorders.

Publication

Our department is committed to conduct clinical and basic research related to Pediatric Hematology Oncology. The faculty and staff in the department are engaged in individual projects and also try to collaborate with other centers to conduct multicentric studies. Some of the research work published in peer review international and national journals is listed.

Verma P, Jain S, Kapoor G, Tripathi R, Sharma P, Doval DC. IAP Chemotherapy Regimen Is a Viable and Cost-effective Option in Children and Adolescents With Osteosarcoma: A Comparative Analysis With MAP Regimen on Toxicity and Survival. J Pediatr Hematol Oncol. 2021 May 1; 43(4):e466-e471. doi: 10.1097/MPH.0000000000001946. PMID: 32925402.
Malhotra P, Kapoor G, Jain S, Jain S, Sharma A. Indian Pediatr. Obesity and Sarcopenia in Survivors of Childhood Acute Lymphoblastic Leukemia. 2021 May 15; 58(5):436-440. doi: 10.1007/s13312-021-2213-7. Epub 2021 Jan 2. PMID: 33408276; PMCID: PMC8139219.
Teotia N, Jain S, Kapoor G, Koneru S.Olanzapine for the Treatment of Breakthrough Vomiting in Children Receiving Moderate and High Emetogenic Chemotherapy. Indian Pediatr. 2020 Nov 15; 57(11):1069-1070. PMID: 33231177.
Kapoor G, Goswami M, Sharma S, Mehta A, Dhillon JK. Assessment of oral health status of children with Leukemia: A cross-sectional study. Spec Care Dentist. 2019 Nov; 39(6):564-571. doi: 10.1111/scd.12419. Epub 2019 Sep 17. PMID: 31529729.
Jain, S., Kapoor, G., Koneru, S. et al. A randomized, open-label non-inferiority study to compare palonosetron and ondansetron for prevention of acute chemotherapy-induced vomiting in children with cancer receiving moderate or high emetogenic chemotherapy. Jain S, Kapoor G, Koneru S, Vishwakarma G. Support Care Cancer. 2018 Sep; 26(9):3091-3097. doi: 10.1007/s00520-018-4158-5. Epub 2018 Mar 22. PMID: 29564625.
Vyas C, Jain S, Kapoor G, Mehta A, Takkar Chugh P. Experience with generic pegylated L-asparaginase in children with acute lymphoblastic leukemia and monitoring of serum asparaginase activity. Pediatr Hematol Oncol. 2018 Aug-Sep; 35(5-6):331-340. doi: 10.1080/08880018.2018.1538277. Epub 2018 Nov 29. PMID: 30488741.
Jain S, Mehta A, Kapoor G, Bhurani D, Jain S, Agrawal N, Ahmed R, Kumar D. Evaluating New Markers for Minimal Residual Disease Analysis by Flow Cytometry in Precursor B Lymphoblastic Leukemia. Indian J Hematol Blood Transfus. 2018 Jan; 34(1):48-53. doi: 10.1007/s12288-017-0845-5. Epub 2017 Jul 3. PMID: 29398799; PMCID: PMC5786637.
Kapoor G, Singh N. Role of apoptotic markers in paediatric acute lymphoblastic leukaemia. Indian J Med Res. 2018 Mar; 147(3):225-227. doi: 10.4103/ijmr.IJMR_906_17. PMID: 29923509; PMCID: PMC6022391.
MALHOTRA P, KAPOOR G, JAIN S, et al. Incidence and Risk Factors For Hypertension During Childhood Acute Lymphoblastic Leukemia Therapy . Indianpediatrics.net/Epub13062018/RB-00125.pdf
Koneru S, Jain S, Kapoor G. A rare case of Acute Megakaryoblastic leukemia with orbital chloroma in a non Down syndrome child Asian journal of oncology journal : 2017 | Volume : 3 | Issue : 1 | Page : 81-83
Jain S, Jain S, Kapoor G*, Virmani A, Bajpai R.No impact of disease and its treatment on bone mineral density in survivors of childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2017 Apr;64(4). doi: 10.1002/pbc.26271. Epub 2016 Sep 26.
Radhakrishnan V, Kapoor G*, Arora B, Bansal D, Vora T, Prasad M, Chinnaswamy G, Laskar S, Agarwala S, Kaur T, Rath GK, Bakhshi S. Management of Hodgkins Lymphoma: ICMR Consensus Document. Indian J Pediatr. 2017 May;84(5):371-381. doi: 10.1007/s12098-017-2304-6. Epub 2017 Mar 30.
Bhethanabhotla S, Jain S, Kapoor G, Mahajan A, Chopra A, Vishnubhatla S, Bakhshi S. Outcome of pediatric advanced Hodgkin lymphoma treated with ABVD and predictors of inferior survival: a multicenter study of 186 patients. Leuk Lymphoma. 2017 Jul;58(7):1617-1623. doi: 10.1080/10428194.2016.1262951. Epub 2016 Dec 6.
Panda SP, Chinnaswamy G, Vora T, Prasad M, Bansal D, Kapoor G, Radhakrishnan V, Agarwala S, Laskar S, Arora B, Kaur T, Rath GK, Bakhshi S. Diagnosis and Management of Rhabdomyosarcoma in Children and Adolescents: ICMR Consensus Document. Indian J Pediatr. 2017 May;84(5):393-402. doi: 10.1007/s12098-017-2315-3. Epub 2017 Apr 5.
Thacker N, Bakhshi S, Chinnaswamy G, Vora T, Prasad M, Bansal D, Agarwala S, Kapoor G, Radhakrishnan V, Laskar S, Kaur T, Rath GK, Dhaliwal RS, Arora B. Management of Non-Hodgkin Lymphoma: ICMR Consensus Document. Indian J Pediatr. 2017 May;84(5):382-392. doi: 10.1007/s12098-017-2318-0. Epub 2017 Apr 5.
Bansal D, Totadri S, Chinnaswamy G, Agarwala S, Vora T, Arora B, Prasad M, Kapoor G, Radhakrishnan V, Laskar S, Kaur T, Rath GK, Bakhshi S. Management of Neuroblastoma: ICMR Consensus Document. Indian J Pediatr. 2017 Jun;84(6):446-455. doi: 10.1007/s12098-017-2298-0. Epub 2017 Apr 3.
Prasad M, Vora T, Agarwala S, Laskar S, Arora B, Bansal D, Kapoor G, Chinnaswamy G, Radhakrishnan V, Kaur T, Rath GK, Bakhshi S. Management of Wilms Tumor: ICMR Consensus Document. Indian J Pediatr. 2017 Jun;84(6):437-445. doi: 10.1007/s12098-017-2305-5. Epub 2017 Apr 3.
Agarwala S, Mitra A, Bansal D, Kapoor G, Vora T, Prasad M, Chinnaswamy G, Arora B, Radhakrishnan V, Laskar S, Kaur T, Dhaliwal RS, Rath GK, Bakhshi S. Management of Pediatric Malignant Germ Cell Tumors: ICMR Consensus Document. Indian J Pediatr. 2017 Jun;84(6):465-472. doi: 10.1007/s12098-017-2308-2. Epub 2017 Apr 1.
Agarwala S, Gupta A, Bansal D, Vora T, Prasad M, Arora B, Kapoor G, Chinnaswamy G, Radhakrishnan V, Laskar S, Kaur T, Dhaliwal RS, Rath GK, Bakhshi S. Management of Hepatoblastoma: ICMR Consensus Document. Indian J Pediatr. 2017 Jun;84(6):456-464. doi: 10.1007/s12098-017-2301-9. Epub 2017 Mar 29.
Jain S, Mehta A, Kapoor G, Bhurani D, Jain S et al Evaluating New Markers for Minimal Residual Disease Analysis by Flow Cytometry in Precursor B Lymphoblastic Leukemia J Hematol Blood Transfus (2017). doi:10.1007/s12288-017-0845-5.
Vyas, C., Jain, S., Kapoor, G. Therapy Related AML/MDS Following Treatment for Childhood Cancer: Experience from a Tertiary Care Centre in North India J Hematol Blood Transfus (2017). doi:10.1007/s12288-017-0845-5.
Jain S, Kapoor G*, Bajpai R. ABVD-Based Therapy for Hodgkin Lymphoma in Children and Adolescents: Lessons Learnt in a Tertiary Care Oncology Center in a Developing Country. Pediatr Blood Cancer. 2016 Jun;63(6):1024-30. doi: 10.1002/pbc.25935. Epub 2016 Feb 8.
V+B3:B24erma P, Jain S, Kapoor G. Complete response to crizotinib in chemotherapy refractory neuroblastoma. South Asian J Cancer. 2016.
Jain S, Kapoor G. Invasive aspergillosis in children with acute leukemia at a resource-limited oncology center. J Pediatr Hematol Oncol. 2015 Jan; 37(1)
Gupta A, Kapoor G, Jain S, Bajpai, R. Absolute Lymphocyte Count Recovery Independently Predicts Outcome in Childhood Acute Lymphoblastic Leukemia: Experience from a Tertiary Care Cancer Centre of a Developing Country. J Pediatr Hematol Oncol. 2015; 37(3) p e143–e149.
Dhamija M, Kapoor G, Juneja A. Infusional chemotherapy and medication errors in a tertiary care pediatric cancer unit in a resource-limited setting. J Pediatr Hematol Oncol. 2014; 36(7): 412-5
Tiwari A, Jain S, Mehta S, Kapoor G et al. Limb salvage surgery for osteosarcoma- early results in Indian patients. Indian J Orthop 2014; 48:266-72.
Tiwari A, Gupta H, Jain S, Kapoor G. Outcome of multimodality treatment of Ewing’s sarcoma of the extremities. Indian J Orthop. 2010; 44(4):378-83.
Das K, Jain S, Chichra A, Gupta H, Kapoor G. Non-hematological tumors of head and neck region in the pediatric age group in a tertiary care cancer center. Pediatr Surg Int. 2011; 27(9):919-23.
Abedin S, Kapoor G. Peripherally inserted central venous catheters are a good option for prolonged venous access in children with cancer. Pediatr Blood Cancer. 2008 Aug; 51(2):251-5.
Kapoor G, Sinha R, Abedin S. Experience with high dose methotrexate therapy in childhood acute lymphoblastic leukemia in a tertiary care cancer centre of a developing country. Pediatr Blood Cancer. 2012; 59(3):448-53.
Kapoor G, Sinha R, Naithani R, Chandgothia M. Thiopurine S-methyltransferase gene polymorphism and 6-mercaptopurine dose intensity in Indian children with acute lymphoblastic leukemia. Leuk Res. 2010; 34(8):1023-6.
Shearer P, Kapoor G, Beckwith JB, Takashima J, Breslow N, Green DM. Secondary acute myelogenous leukemia in patients previously treated for childhood renal tumors: a report from the National Wilms Tumor Study Group. J Pediatr Hematol Oncol. 2001; 23(2):109-11.
Kapoor G, Advani SH, Dinshaw KA, Muckaden MA, Soman CS, Saikia TK, Gopal R, Nair CN, Kurkure PA, Pai SK, et al. Treatment results of Hodgkin’s disease in Indian children. Pediatr Hematol Oncol. 1995; 12(6):559-69.
Kapoor G, Advani SH, Nair CN, Pai K, Kurkure PA, Nair R, Saikia TK, Vege D, Desai PB. Pediatric germ cell tumor. An experience with BEP. J Pediatr Hematol Oncol. 1995; 17(4):318-24.
Parikh PM, Kulkarni S, Kapoor G, Sastry PS, Saikia TK, Gopal R, Kurkure PA, Nair CN, Pai SK, Pai VR, et al. Role of growth factors in hastening hematopoietic recovery following HLA matched sibling allogeneic bone marrow transplantation. J Assoc Physicians India. 1995 Jun; 43(6):404-5.
Kapoor G, Maitra A; Somlata, Brahmachari V. Application of SNaPshot for analysis of thiopurine methyltransferase gene polymorphism. Indian J Med Res. 2009; 129(5):500-5.
Jain S, Kapoor G. How to treat relapsed acute lymphoblastic leukemia: transplant vs. conventional chemotherapy. Indian J Pediatr. 2013 Oct; 80(10):846-52.
Jain S. and Kapoor, G. Chemotherapy in Ewing’s sarcoma. Indian Journal of Orthopaedics. 2010; 44, 369-377.
Kapoor G, Das K. Soft tissue sarcomas in children. Indian J Pediatr. 2012; 79(7):936-42.
Jain S, Kapoor G. Chemotherapy in Ewing’s sarcoma. Indian J Orthop. 2010; 44(4):369-77.
Arora RS, Eden TO, Kapoor G. Epidemiology of childhood cancer in India. Indian J Cancer. 2009; 46(4):264-73.
Yadav, S. P., Kharya, G., Mohan, N., Sehgal, A., Bhat, S., Jain, S., Kapoor, G. and Sachdeva, A. Langerhans cell involvement. Pediatric Blood histiocytosis with digestive tract & Cancer. 2010; 55, 748-753.
Jain S, Kapoor G. Severe life threatening neurotoxicity in a child with acute lymphoblastic leukemia receiving posaconazole and vincristine. .Pediatr Blood Cancer. 2010; 54(5):783.
Jain S, Naithani R, Kapoor G, Nath Triloki. L-asparaginase induced severe hypertriglyceridemia in acute lymphoblastic leukemia with 11q23 abnormality Leuk Res. Volume 33, Issue 11:194.
Saha Rajat, Jain S, Naithani R, Kapoor G. Chemotherapy induced palmoplantar erythrodysesthesia in a child with Burkitt lymphoma. Pediatr Blood Cancer. 2009 Oct; 53(4):682.
Gupta A, Jain S, Kapoor G. Successful outcome of mucormycosis in two children on induction therapy for acute lymphoblastic leukemia. Indian J Med Paediatr Oncol. 2013; 34(4):313-6.
Jain S, Jain S, Kapoor G. Imatinib-associated massive upper gastrointestinal hemorrhage and hepatic encephalopathy in a child with Philadelphia positive acute lymphoblastic leukemia: A case report and review of the literature. South Asian J Cancer. 2014 Oct; 3(4):234-5.
Pavithran K, Kapoor G. Acute myeloid leukemia in a child with Goldenhar syndrome. Med Pediatr Oncol. 2002; 38(6):451-2.
Kapoor G, Bajpai S, Nair CN, Badrinath Y, Gladstone B, Advani SH. Call a positive acute lymphoblastic leukemia after etoposide-based therapy for Ewing’s sarcoma. Leuk Res. 1995; 19(10):771-2.
Kapoor G, Kadam PR, Chougule A, Gladstone B, Advani SH. Secondary ANLL with t (11; 19) (q23; p13) following etoposide and cisplatin for ovarian germ cell tumor. Indian J Cancer. 1997; 34(2):84-7.
Kapoor G, Goswami M, Sharma S, Mehta A, Dhillon JK. Assessment of oral health status of children with Leukemia: A cross-sectional study. Spec Care Dentist. 2019 Nov; 39(6):564-571. doi: 10.1111/scd.12419. Epub 2019 Sep 17. PMID: 31529729.
Teotia N, Jain S, Kapoor G, Koneru S.Olanzapine for the Treatment of Breakthrough Vomiting in Children Receiving Moderate and High Emetogenic Chemotherapy. Indian Pediatr. 2020 Nov 15; 57(11):1069-1070. PMID: 33231177.
Role of apoptotic markers in paediatric acute lymphoblastic leukaemia. Kapoor G, Singh N. Indian J Med Res. 2018 Mar; 147(3):225-227. doi: 10.4103/ijmr.IJMR_906_17. PMID: 29923509; PMCID: PMC6022391.
Incidence and Risk Factors for Hypertension during Childhood Acute Lymphoblastic Leukemia Therapy. Malhotra P, Kapoor G, Jain S, Garg B. Indian Pediatr. 2018 Oct 15; 55(10):877-879. Epub 2018 Jul 13. PMID: 29941701.
Experience with generic pegylated L-asparaginase in children with acute lymphoblastic leukemia and monitoring of serum asparaginase activity. Vyas C, Jain S, Kapoor G, Mehta A, Takkar Chugh P. Pediatr Hematol Oncol. 2018 Aug-Sep; 35(5-6):331-340. doi: 10.1080/08880018.2018.1538277. Epub 2018 Nov 29. PMID: 30488741.
Obesity and Sarcopenia in Survivors of Childhood Acute Lymphoblastic Leukemia. Malhotra P, Kapoor G, Jain S, Jain S, Sharma A. Indian Pediatr. 2021 May 15; 58(5):436-440. doi: 10.1007/s13312-021-2213-7. Epub 2021 Jan 2. PMID: 33408276; PMCID: PMC8139219.
Symptomatic Cerebral Sinovenous Thrombosis Associated With L-Asparaginase In Children With Acute Lymphoblastic Leukemia: A Single Institution Experience Over 17 Years. Malhotra P, Jain S, Kapoor G. J Pediatr Hematol Oncol. 2018 Oct; 40(7):e450-e453. doi: 10.1097/MPH.0000000000001127. PMID: 29554021.
A randomized, open-label non-inferiority study to compare palonosetron and ondansetron for prevention of acute chemotherapy-induced vomiting in children with cancer receiving moderate or high emetogenic chemotherapy. Jain S, Kapoor G, Koneru S, Vishwakarma G. Support Care Cancer. 2018 Sep; 26(9):3091-3097. doi: 10.1007/s00520-018-4158-5. Epub 2018 Mar 22. PMID: 29564625.
Evaluating New Markers for Minimal Residual Disease Analysis by Flow Cytometry in Precursor B Lymphoblastic Leukemia. Jain S, Mehta A, Kapoor G, Bhurani D, Jain S, Agrawal N, Ahmed R, Kumar D. Indian J Hematol Blood Transfus. 2018 Jan; 34(1):48-53. doi: 10.1007/s12288-017-0845-5. Epub 2017 Jul 3. PMID: 29398799; PMCID: PMC5786637.
Therapy Related AML/MDS Following Treatment for Childhood Cancer: Experience from a Tertiary Care Centre in North India. Vyas C, Jain S, Kapoor G. Indian J Hematol Blood Transfus. 2018 Jan; 34(1):78-82. doi: 10.1007/s12288-017-0840-x. Epub 2017 Jun 19. PMID: 29398803; PMCID: PMC5786633.
IAP Chemotherapy Regimen Is a Viable and Cost-effective Option in Children and Adolescents With Osteosarcoma: A Comparative Analysis With MAP Regimen on Toxicity and Survival. Verma P, Jain S, Kapoor G, Tripathi R, Sharma P, Doval DC. J Pediatric Hematol Oncol. 2021 May 1; 43(4):e466-e471. doi: 10.1097/MPH.0000000000001946. PMID: 32925402.
Outcome of pediatric advanced Hodgkin lymphoma treated with ABVD and predictors of inferior survival: a multicenter study of 186 patients. Bhethanabhotla S, Jain S, Kapoor G, Mahajan A, Chopra A, Vishnubhatla S, Bakhshi S. Leuk Lymphoma. 2017 Jul; 58(7):1617-1623. doi: 10.1080/10428194.2016.1262951. Epub 2016 Dec 6. PMID: 27919174.
Choice of Local Therapy in Children with Ewing Sarcoma. Kapoor G, Jain S. Indian Pediatr. 2020 Jun 15; 57(6):503-504. PMID: 32562393.
Complete response with crizotinib in two children with chemotherapy resistant neuroblastoma. Verma P, Jain S, Kapoor G. South Asian J Cancer. 2017 Apr-Jun; 6(2):89-90. doi: 10.4103/2278-330X.208855. PMID: 28702420; PMCID: PMC5506823.
No impact of disease and its treatment on bone mineral density in survivors of childhood acute lymphoblastic leukemia. Jain S, Jain S, Kapoor G, Virmani A, Bajpai R. Pediatr Blood Cancer. 2017 Apr; 64(4). doi: 10.1002/pbc.26271. Epub 2016 Sep 26. PMID: 27671543.
Infusional chemotherapy and medication errors in a tertiary care pediatric cancer unit in a resource-limited setting. Dhamija M, Kapoor G, Juneja A. J Pediatr Hematol Oncol. 2014 Oct; 36(7):e412-5. doi: 10.1097/MPH.0000000000000044. PMID: 24136029.
ABVD-Based Therapy for Hodgkin Lymphoma in Children and Adolescents: Lessons Learnt in a Tertiary Care Oncology Center in a Developing Country. Jain S, Kapoor G, Bajpai R. Pediatr Blood Cancer. 2016 Jun; 63(6):1024-30. doi: 10.1002/pbc.25935. Epub 2016 Feb 8. PMID: 26855007.
Absolute Lymphocyte Count Recovery Independently Predicts Outcome in Childhood Acute Lymphoblastic Leukemia: Experience From a Tertiary Care Cancer Center of a Developing Country. Gupta A, Kapoor G, Jain S, Bajpai R.J Pediatr Hematol Oncol. 2015 Apr; 37(3):e143-9. doi: 10.1097/MPH.0249. PMID: 26201035.

Conferences and Workshops

The mission of department is to provide world class standard of care treatment to children with cancer. In addition, department lays emphasis on increasing awareness about childhood cancers amongst community physicians. In our pursuit to achieve this mission our department regularly conducts workshops, CMEs and conferences to improve the skill and knowledge of our staff and as well as sensitize general physicians about the importance of early diagnosis and appropriate treatment.
Central Venous Access: Challenges and Choices Preconference Workshop under the aegis of Pediatric Hematology Oncology Chapter of IAP for National Pediatric Conference; PEDICON 2015 on 21st January 2015.
First Indian Cancer Congress 2013 (ICC 2013) jointly hosted by (AROI / IASO / ISMPO and ISO)
Pediatric Oncology Session of this international conference was conducted by our department on 24th November 2013.
Workshop for Nurses Preconference Workshop under the aegis of Pediatric Hematology Oncology Chapter of IAP for National Pediatric Conference; PHOCON 2013 on 18th October 2013.
National training project in Practical Pediatric Hematology under the aegis of Pediatric Hematology Oncology Chapter of IAP in October 2012, RGCIRC, Delhi.
“Malignancies in Childhood” RGCON 2011 – 10th Annual International Conference of the Rajiv Gandhi Cancer Institute and Research Centre, Delhi on February 5th – 6th 2011 at Indian Habitat Centre endorsed by SIOP (International Society of Pediatric Oncology), UICC, Pediatric Hematology-Oncology chapter of Indian Academy of Pediatrics and the ISMPO.
National Training Project in Practical Pediatric Oncology under the aegis of Pediatric Hematology Oncology Chapter of IAP and SIOP (Society of International Pediatric Oncology) on May 10th and 11th 2008.
Nutrition and Supportive Care and Radiotherapy in Pediatric Cancers Preconference Workshops for National Conference on Pediatric Hematology and Oncology (PHOCON) on 7th Nov 2008.

Current Clinical Trial

A phase I/II Study of Sunitinib in young patients with advanced Gastrointestinal Stromal Tumor (CTRI/2015/03/005609 [Registered on: 05/03/2015] Trial Registered Prospectively)
Indian childhood collaborative leukemia croup (ICICLE-I): A collaborative, multicentre, national trial for newly diagnosed patients with acute lymphoblastic leukemia.
InPOG HL-15-01 multicentre study
InPOG LE -16-01 multicentre study
InPOG Wilms tumor multicentre study
A Phase II open-label, single-arm, multi-center study of ruxolitinib added to corticosteroids in pediatric subjects with moderate and severe chronic graft vs. host disease after allogeneic stem cell transplantation.