DONATEACUTE MYELOID LEUKEMIA (AML)
Overview
Acute lymphoblastic leukemia (ALL) is the commonest childhood cancer. It constitutes one fourth to one third of all pediatric malignancies and 75% of all leukemias.In India, each year over 6000 children < 15 years of age will develop ALL.
Signs and Symptoms
Persistent fever, fatigue, pallor, malaise, bleeding, bone and joint pain, enlargement of lymph node, spleen, liver
Cause and Risk Factors
A number of acquired and genetic predisposing factors and inciting agents have been described for AML. The genetic factors include Down syndrome, Fanconi anemia, Bloom syndrome, Kostmann syndrome, Diamond Blackfan anemia, paroxysmal nocturnal haemoglobinuria, Li-Fraumeni syndrome, neurofibromatosis etc. Well established inciting agents include exposure to benzene, alkylating agents (AML M1, M2) nitrosoureas, epipodophyllotoxins (M4, M5)and ionizing radiation. A link between infectious agents and AML has not been established.
